Zhibo LIU
Contact：zbliu@cpl.ac.cn
Education
2010.09–2014.09, Ph.D. in Radiopharmaceutical Chemistry, Department of Chemistry, University of British Columbia, Advisor: Dr. David M. Perrin
2006.09–2010.07, B.S. in Chemistry, College of Chemistry and Chemical Engineering, Nanjing University
Academic Experience
2023- present, Professor, College of Chemistry and Molecular Engineering, Peking University
2016–present, Principal Investigator, Peking-Tsinghua Centre for Life Sciences
2016–2022, Tenure-Tracked Assistant Professor, Tenured Associate Professor, Vice Chair (since 2019), College of Chemistry and Molecular Engineering, Peking University
2014–2016, Postdoctoral Research Fellow in Nuclear Medicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Overview of Academic Research
Imaging-guided in vivo desilylation cleavage chemistry that perturbs biological process;
Radiotherapy-induced controlled drug release in tumors;
Production of medical radionuclides and development of radiopharmaceuticals for cancer theranostics.
Major Honor and Awards
2022, The National Science Fund for Distinguished Young Scholars
2021.06, “Ones to Watch” for 2021, Society of Nuclear Medicine and Molecular Imaging
2021.04, Young Scholar Award, Chinese Chemistry Society
2020.09, Teaching Excellence Award, Peking University
2019.12, WuXi Eminent Young Scholar Award, WuXi-AppTech
2018.11, Fairchild Award, International Society of Neutron Capture Therapy
2018.11, Luye Eminent Young Scholar Award, Peking University
2016.06, Distinguished Scientist Award, NIH-CSSA Committee
2015.06, Michael J. Welch Postdoctoral Grant, Society of Nuclear Medicine and Molecular Imaging
2015.06, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
2015.04, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
2014.08, Edward Piers Memorial Award, Edward Piers Foundation
2014.06, Chinese Government Award for Outstanding Abroad Students, Chinese Government
2013.06, Young Scientist Award, 37th CASNM
2013.05, Graduate Student Travel Award, Chemistry Department, UBC
2013.02, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation
2010.03, Tsang Hin-chi Academic Award, Tsang Hin-chi Foundation
2006.01, Silver Medal, 21th Chinese Chemistry Olympiad
Representative Research Achievements
1. Qinyang Wang#, Yupeng Wang#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*. A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426.
2. Zhibin Guo#, Hanyu Hong#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, doi: 10.1002/anie.202205014.
3. Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8, 837.
4. Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*. Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat. Commun., 2022, 13, 2143.
5. Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*. Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors. J. Am. Chem. Soc., 2022, doi.org/10.1021 /jacs.2c02521
6. Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*. Cationic Micelle as An In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 60, 19750–19758.
7. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*. Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255.
8. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*. External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552.
9. Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*. Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy. Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996.